Monte Carlo simulation of PET based on Three-photon annihilation with Compton Cameras

Stage numéro : M2-1819-IM-01
Laboratoire :Centre de Physique des Particules de Marseille Case 902
 163 avenue de Luminy - 13288 Marseille Cedex 9
Directeur :Cristinel Diaconu - 04.91.82.72.01 - diaconu@cppm.in2p3.fr
Correspondant :William Gillard - 04.91.82.72.67 - gillard@cppm.in2p3.fr
Groupe d'accueil :imXgam
Chef de groupe :Christian Morel - 04.91.82.76.73 - morel@cppm.in2p3.fr
Responsable de stage :Mathieu Dupont - mdupont@cppm.in2p3.fr

Thématique : Physique des particules

Positron emission tomography (PET) is a technique that uses specially designed positron emitting radioactive tracers to image the functions of the body non-invasively. In conventional PET, the basic process employed is the annihilation of an emitted positron and an electron that results in two almost co-linear gamma-photons traveling in opposite directions, each with 511 keV energy. The measure of this gammas by opposite detectors give us line of response (LOR), and images of radioactive tracers are computing by accumulation of this LOR.

From time to times (rate < 5% in water), annihilation results in three coplanars photons. The low rate is compensated by the fact that detection of the three gammas gives directly the position of annihilation (from the measurement of energy and the use of momentum conservation [1]).

The objective of this internship will be 3-photon imaging by using three Compton cameras. Compton cameras have large field of view with a high sensitivity which are key advantages for this application.

The trainee will simulate with the help of GATE (Monte carlo software, [2]) the three-photon annihilation and detection with Compton cameras with the GATE Monte Carlo simulation software [2].

Main tasks will be to:


- Implement three-photon annihilation in GATE


- Simulate the imaging setup comprising three Compton cameras


- Start to establish hardware requirements needed for Compton cameras in order to compete conventional PET

[1] Abuelhia, E., Kacperski, K. Spyrou, N.M. J Radioanal Nucl Chem (2007) 271: 489. https://doi.org/10.1007/s10967-007-0235-9

[2] Jan S. et al., “GATE a simulation toolkit for PET and SPECT”. Phys. Med. Biol., 2004, 49, 4543